Mouse Kidney Parvovirus (MKPV), a recently identified parvoviral pathogen, has garnered attention due to its association with inclusion body nephropathy (IBN), a condition documented anecdotally for over 40 years. Histopathologic lesions, characterised by epithelial intranuclear inclusions in renal tubules, have been observed in both immunodeficient and immunocompetent mice.

Recent research attributes these lesions to a novel parvovirus in the Chapparvovirus genus, known as MKPV or Murine Chapparvovirus (MuCPV). MKPV is genetically divergent from other known mouse Protoparvoviruses such as Minute Virus of Mice (MVM) and Mouse Parvovirus (MPV). There is no cross-reaction between MKPV and these distinct types of Parvoviruses when testing serologically, though there is between MVM and MPV.

MKPV is spread by the faecal-oral or urinary-oral route, kidneys show a persistent infection by 61 days in an endemically infected colony, while consistent viremia was delayed until approximately 100 days of life. This means detection in younger mice may be unreliable.

At Surrey Diagnostics, we offer an MKPV diagnostic test as part of our Expanded Serology Panel, samples include bloodspots and serum. We also offer a specific MKPV PCR which can be run on faeces, Exhaust Air Dust (EAD), and Sentinel Free Diagnostic (SFD) samples. Kidney & urine samples can additionally be tested via PCR.

With our MKPV testing services, here at Surrey Diagnostics, we are committed to providing reliable and comprehensive solutions for monitoring and managing MKPV infections in laboratory mouse populations. By staying at the forefront of emerging viruses, we contribute to maintaining mouse welfare and research reliability in laboratory settings.

If you have any questions regarding MKPV and how it may impact animal welfare or research in your facility, please don’t hesitate to contact us and we will be happy to help.