Genotyping & Genetic Drift Screening

Surrey Diagnostics offers a comprehensive suite of genetic screening services tailored specifically to your transgenic animal colonies. We prioritise confidentiality, ensuring that all screening processes are conducted discreetly to meet your individual requirements.

The use of transgenic animals has witnessed a significant rise in recent years, necessitating the screening of breeding colonies to identify progeny carrying the desired genetic modifications.

Many research facilities encounter challenges in organising in-house screening, leading to an accumulation of untested mice within the facility, occupying valuable housing space. This becomes particularly crucial with the introduction of Full Economic Costing. To address these concerns, Surrey Diagnostics provides a seamless solution by conducting the screening for you.

By relying on our expert genetic screening services, you can streamline your research operations, optimise resources, and accelerate the advancement of your scientific endeavours. We stand committed to delivering top-tier services that contribute to the success and efficiency of your transgenic animal studies.

Customised PCR Tests

For Surrey Diagnostics to develop a customised PCR test to meet your specific requirements, we kindly request the following essential components:

1. Primer Sequences or Prepared Primers: Providing us with the primer sequences you intend to use or the primers you have already prepared will facilitate the test development process.

2. Homozygous Positive Test Sample: An appropriate test sample that demonstrates homozygous positivity for the modification is necessary for accurate validation.

3. Heterozygous Test Sample: Additionally, a test sample displaying heterozygosity for the modification is vital for comprehensive validation.

4. Basic Standard Operating Procedure (SOP): A basic SOP outlining the experimental steps and procedures will be indispensable in guiding the test development process.

Once the PCR test is successfully validated, your samples can be processed at an impressive rate of nearly 100 samples per day for straightforward one-step PCR tests. The test samples may consist of tail clips or samples of hair bulbs. Rest assured that our state-of-the-art facilities and expertise ensure efficient and precise analysis, supporting your research objectives and genetic modification screening needs.

Ob Gene Screening: At Surrey Diagnostics, we offer efficient screening services for the ob gene in your animal colonies. The test sample can be obtained through ear clips, or hair bulb samples. This approach eliminates the need to retain animals until the phenotype becomes evident. Leveraging PCR testing, our services allow for the immediate identification of animals as ob/ob, ob/+, or +/+ genotypes.

Sex Determination: Our expertise extends to screening any mammalian species for gender determination through sex chromosomes. Blood, tissue, or hair bulb samples can be used as the test sample. PCR screening for the xx/yy genes allows you to identify the sex of undeveloped foetuses or animals with abnormal development.

By relying on our standard genotyping tests, you can streamline your research operations, reduce animal retention requirements, and obtain rapid and accurate results.